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however, these findings have not yet been consistently replicated in human trials

Improving total antioxidant capacity and supporting better detoxification from electrophilic compounds in the seminal fluid may present an integrative approach to supporting fertility, especially in couples with male-factor infertility or unexplained infertility .

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Studies have shown that in contrast to a normal liver, there is an upregulation of FZD3/6/7 and Wnt3/4/5a expression in 95% of HCC and 68% of the surrounding tumor tissues, along with downregulation of sFRP1/5, which accumulates progressively with tumor advancement and the severity of fibrosis in surrounding tissues (72)